Isoxsuprine Hydrochloride

Generic Name:
Isoxsuprine Hydrochloride

Brand Name:
Duvadilan

Available Forms:
Tablets: 10 mg and 20 mg

Indications and Dosages:
For the relief of symptoms associated with cerebrovascular insufficiency.

In the peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease.



Dosage, Frequency and Route
Oral: Adults: 10-20 mg 3-4 times/day; start with lower dose in elderly due to potential hypotension

Action
Vasodilator

A beta adrenergic agonist that cause direct relaxation of uterus and vascular smooth muscles. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin.

Route of Administration
P.O. – by mouth

Side Effects:
CV: Hypotension, tachycardia, chest pain
CNS: Central nervous system: Dizziness
Dermatologic: Rash
GI: Nausea, vomiting
Neuromuscular & skeletal: Weakness

Contraindications:
Hypersensitivity to isoxsuprine or any component of the formulation; presence of arterial bleeding; do not administer immediately postpartum

Nursing Considerations:
• May cause skin rash; discontinue use if rash occurs; arise slowly from prolonged sitting or lying position.